Displaced Myonuclei in Cancer Cachexia Suggest Altered Innervation
نویسندگان
چکیده
منابع مشابه
Altered expression of skeletal muscle myosin isoforms in cancer cachexia.
Cachexia is commonly seen in cancer and is characterized by severe muscle wasting, but little is known about the effect of cancer cachexia on expression of contractile protein isoforms such as myosin. Other causes of muscle atrophy shift expression of myosin isoforms toward increased fast (type II) isoform expression. We injected mice with murine C-26 adenocarcinoma cells, a tumor cell line tha...
متن کاملCachexia in Cancer Patients
Cancer is a leading cause of death worldwide [1]. Besides, overall survival of cancer patients is negatively affected by the presence of comorbidities. In this context, more than one-half of all cancer patients suffer from cachexia. Cachexia is a debilitating condition with high incidence in cancer patients and may lead to delayed, missed, or decreased treatments [2]. Cancer cachexia (CC) has b...
متن کاملCancer Cachexia
Cancer anorexia-cachexia (CACS) is defined as a multifactorial syndrome characterized by ongoing loss of skeletal muscle mass that cannot be fully reversed by conventional nutritional support and leads to progressive functional impairment [1]. Cancer cachexia occurs across a continuum, varying in severity and stage; according to new classification we have pre-cachexia (early clinical signs of c...
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Methods and Results We model an anaerobic component of tumor energy metabolism to assess its impact and contribution to cachexia. In this model, with a high level of anaerobic energy production, the energetic cost to sustain the tumor may reach or exceed 394 kcal/ day per kg of tumor. In addition, the tumor’s high level of glucose and glutamine consumption causes muscle breakdown to fuel the tu...
متن کاملMetalloproteinase expression is altered in cardiac and skeletal muscle in cancer cachexia.
Cardiac and skeletal muscle dysfunction is a recognized effect of cancer-induced cachexia, with alterations in heart function leading to heart failure and negatively impacting patient morbidity. Cachexia is a complex and multifaceted disease state with several potential contributors to cardiac and skeletal muscle dysfunction. Matrix metalloproteinases (MMPs) are a family of enzymes capable of d...
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ژورنال
عنوان ژورنال: International Journal of Molecular Sciences
سال: 2020
ISSN: 1422-0067
DOI: 10.3390/ijms21031092